In 1840, Carl Julius Fritzsche (1808–1871) treated indigo with caustic potash and obtained an oil that he named aniline, after an indigo-yielding plant, anil (Indigofera suffruticosa). Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness. Afternoon dress, 1878. Med Toxicol Adverse Drug Exp 1989; 4: 387-92. They come in a variety of colors, and are known for their clarity. human is 10 grams. These include, gastric lavage, the administration of methylene blue and exchange transfusion. Apply dye liberally to assure even absorption and color saturation. [books.google.com], […] amounts of aniline for short periods of time decreases the ability of blood to carry oxygen .Lack of oxygen causes effects ranging from severe headache, nausea, sometimes vomiting, to dryness of throat and loss of appetite Central nervous symptoms: confusion Aniline itself is a very toxic substance. A Madrid-based company imported denaturated rapeseed oil, dyed by aniline yellow to mark it as unsuitable for human consumption, to be used as a fuel in steel mills. 76000 C.I. [amboss.com], Prognosis One of the hallmarks of phosgene toxicity is an unpredictable asymptomatic latent phase before the development of noncardiogenic pulmonary edema. He named it kyanol or cyanol. [emedicine.medscape.com], What, then, of the epidemiology that the WHO in 1992 was boldly to describe as "comprehensive and exacting epidemiological studies, subjected to critical independent assessment"? [haz-map.com], In case of poisoning A. in the lungs cases, there are complaints of weakness, fatigue, dizziness, headache; blueness of the lips, ears, nail phalanxes; in the blood metgemoglobin killed Ganza. Historically, these dyes have also been proven to cause blindness in some cases when used in the eye areas. [medicalency.com], […] or inhalation of styrene released from disposed packaging materials, cigarette smoke, automobile emissions, or manufacturing of automobile parts, fiberglass, plastic pipes, and insulation for wiring and appliances Effects (mainly due to inhalation) Fatigue Silk taffeta. 3. [nature.com], Important factors in treatment are discussed. Aniline dye is known to produce even colors, it does not blotch, and it dries with a clean look. Aniline wood dye and wood stain are both used for similar purposes – to add color. Chronic manifestations include weakness, peripheral neuropathy, […] eat cigarettes, marked by stimulation and then depression of the central and autonomic nervous systems, and sometimes death from respiratory paralysis. [flipper.diff.org], The symptoms of methemoglobinemia differ depending on the concentration level of MetHb in the blood, with 0–20% potentially producing cyanoderma; 20–40% potentially producing headache, anxiety, vertigo, and a frequent pulse; 40–60% potentially producing The possibility of a late haemolytic reaction being a complication of methylene blue treatment is mentioned. However it is very dangerous to avoid drinking, despite the possible vomiting.At any sign of dehydration (fatigue. Shipped in casks. If you have suggestions or corrections, please contact us. Acute exposure to skin, airways or gastrointestinal tract may cause cyanosis, methaemoglobinaemia, headache, shallow respiration, dizziness, confusion. This dye created a beautiful lustrous colour that Perkin patented and which became known as ‘aniline violet’ or ‘mauveine’. (1,2) Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg… Drug overdoses cause a range of symptoms, including excitability, sleepiness. [ch.ic.ac.uk], In acute poisoning aniline in mild cases, victims complain of weakness, dizziness, headache pain ; marked blueness of the lips, ears, nail phalanxes; in the blood metgemoglobin killed Ganza. 3 - Designer unknown. These new aniline dyes became very fashionable. [books.google.com], Severity of symptoms can range from headache and nausea to convulsions and death. Acute inhalation exposure to high levels of aniline in humans has resulted in effects on the lung, such as upper respiratory tract irritation and congestion. A comprehensive textbook of adult emergency medicine for trainee doctors - covers all the problems likely to present to a trainee in the emergency department. Contacting the poison control center or hospital emergency room is the first step in getting proper treatment. During the manufacturing process for aniline leather, the tanned animal hide is dyed in a drum with aniline dyes. Leather sole, and uppers of silk satin with applied silk braid.. London: V&A Museum, T.588&A-1913. The dyes we use today are much less toxic than aniline. To better understand the reaction he tested the procedure using aniline and created a crude black product that ‘when purified, dried and digested with spirits of wine gave a mauve dye’. Blood, Cardiovascular system silk in different shades of purple more valuable olive for... Off all excess dye remaining on the poison swallowed or inhaled silk and ruching ;:! `` Administration of methylene blue treatment is mentioned and endocrine effects had conflicting results is synthesized by hydrogenation... Exposed to and for how long %. attempt at accuracy has been reported to cause blindness in some when... 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